Levsin

Adult Dosing .

Dosage forms:  TAB: 0.125 mg; SL TAB: 0.125 mg; INJ: 0.5 mg per mL

Dosage Forms Discontinued in US

[drops, elixir not avail. as brand; see generic]

GI tract spasm

[0.125-0.25 mg PO/SL q4h prn]

Max: 1.5 mg/day; Alt: 0.25-0.5 mg SC/IM/IV q4h prn

bladder spasms

[0.125-0.25 mg PO/SL q4h prn]

Max: 1.5 mg/day; Alt: 0.25-0.5 mg SC/IM/IV q4h prn

IBS, adjunct tx

[0.125-0.25 mg PO/SL q4h prn]

Max: 1.5 mg/day; Alt: 0.25-0.5 mg SC/IM/IV q4h prn

PUD, adjunct tx

[0.125-0.25 mg PO/SL q4h prn]

Max: 1.5 mg/day; Alt: 0.25-0.5 mg SC/IM/IV q4h prn

Parkinson dz, adjunct tx

[0.125-0.25 mg PO/SL q4h prn]

Max: 1.5 mg/day; Alt: 0.25-0.5 mg SC/IM/IV q4h prn; Info: to decr. rigidity, tremor, sialorrhea, hyperhidrosis

biliary colic, adjunct

[0.125-0.25 mg PO/SL q4h prn]

Max: 1.5 mg/day; Alt: 0.25-0.5 mg SC/IM/IV q4h prn

renal colic, adjunct tx

[0.125-0.25 mg PO/SL q4h prn]

Max: 1.5 mg/day; Alt: 0.25-0.5 mg SC/IM/IV q4h prn

rhinitis

[0.125-0.25 mg PO/SL q4h prn]

Max: 1.5 mg/day; Alt: 0.25-0.5 mg SC/IM/IV q4h prn

diagnostic procedures

[0.25-0.5 mg SC/IM/IV x1]

Start: 5-10min before procedure; Info: to decr. motility

anesthesia adjunct

[5 mcg/kg/dose SC/IM/IV x1]

Start: 30-60min before anesthesia; Info: to decr. secretions, block vagal inhibitory reflexes and bradycardia

surgery adjunct

[0.125 mg IV prn]

Info: to decr. drug-induced bradycardia

cholinesterase inhibitor overdose

[dosing varies]

Info: give 0.3-0.6 mg IV for each 0.5-2 mg neostigmine or physostigmine or 10-20 mg pyridostigmine

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 0.125 mg; SL TAB: 0.125 mg; INJ: 0.5 mg per mL

Dosage Forms Discontinued in US

[drops, elixir not avail. as brand; see generic]

colic, infantile

[<2 yo, 3.4-4.9 kg]

Dose: 4 drops PO q4h prn; Max: 24 drops/24h; Info: use 0.125 mg per mL solution

[<2 yo, 5-6.9 kg]

Dose: 5 drops PO q4h prn; Max: 30 drops/24h; Info: use 0.125 mg per mL solution

[<2 yo, 7-9.9 kg]

Dose: 6 drops PO q4h prn; Max: 36 drops/24h; Info: use 0.125 mg per mL solution

[<2 yo, >10 kg]

Dose: 8 drops PO q4h prn; Max: 40 drops/24h; Info: use 0.125 mg per mL solution

bladder or GI tract spasms

[2-11 yo]

Dose: 0.0625-0.125 mg PO/SL q4h prn; Max: 0.75 mg/day

[12 yo and older]

Dose: 0.125-0.25 mg PO/SL q4h prn; Max: 1.5 mg/day

anesthesia adjunct

[>2 yo]

Dose: 5 mcg/kg/dose SC/IM/IV x1; Start: 30-60min before anesthesia; Info: to decr. secretions, block vagal inhibitory reflexes and bradycardia

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[not defined]