Kedbumin

Adult Dosing .

Dosage forms:  INJ (25%): 12.5 g per 50 mL, 25 g per 100 mL

hypovolemia

[25 g IV x1]

Max: 2 g/kg/day; Info: may repeat dose x1 after 15-30min

hypoalbuminemia

[50-75 g IV x1]

Max: 2 g/kg/day; Info: for pts w/ hypovolemia

burns

[individualize dose IV]

Start: 25 g IV x1 >24h after burn injury, then adjust dose to maintain plasma protein concentration 2.5 g/100 mL or serum protein concentration 5.2 g/100 mL; Max: 2 g/kg/day

ARDS

[25 g IV x1]

Max: 2 g/kg/day; Info: may repeat dose q8h up to 3 days

ovarian hyperstimulation syndrome

[50-100 g IV x1]

Max: 2 g/kg/day; Info: may repeat dose q4-12h prn

paracentesis

[6-8 g IV per 1000 mL ascitic fluid removed]

Max: 2 g/kg/day; Info: for ascites removal >4 L

nephrotic syndrome (off-label)

[25 g IV qd x7-10 days]

Max: 2 g/kg/day; Info: use w/ diuretics

plasmapheresis (off-label)

[individualize dose IV]

Max: 2 g/kg/day; Info: for large volume plasma exchange

spontaneous bacterial peritonitis (off-label)

[1.5 g/kg/dose IV x1, then 1 g/kg/dose IV on day 3]

Info: give first dose w/in 6h of detection; use w/ antibiotics

hepatorenal syndrome (off-label)

[20-40 g IV qd]

Start: 1 g/kg/dose IV x1; Max: 100 g/initial dose; 2 g/kg/day; Info: use w/ vasoconstrictors

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ (25%): 12.5 g per 50 mL, 25 g per 100 mL

hypovolemia

[<1 mo]

Dose: 0.5-1 g/kg/dose IV x1; Max: 2 g/kg/day; Info: may repeat dose x1 after 15-30min

[1 mo-12 yo]

Dose: 0.5-1 g/kg/dose IV x1; Max: 2 g/kg/day; Alt: 2.5-12.5 g IV x1; Info: may repeat dose x1 after 15-30min

[13 yo and older]

Dose: 25 g IV x1; Max: 2 g/kg/day; Info: may repeat dose x1 after 15-30min

hypoalbuminemia

[0.5-1 g/kg/dose IV x1]

Info: for pts w/ hypovolemia

neonatal hemolytic dz (off-label)

[1 g/kg/dose IV x1]

Info: give 1h before exchange transfusion

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[not defined]