Select a medication above to begin.
nafcillin
generic
Adult Dosing .
Dosage forms: INJ
infections, bacterial
- [0.5-2 g IV q4-6h]
- Max: 12 g/day IV; Info: dose, duration varies w/ infection type, severity
osteomyelitis
- [1-2 g IV q4h x4-6wk]
- Max: 12 g/day
meningitis, bacterial
- [100-200 mg/kg/day IV divided q4-6h]
- Max: 12 g/day
endocarditis
- [native valve]
- Dose: 2 g IV q4h x4-6wk; Max: 12 g/day; Info: duration varies w/ infection severity; give x2wk if uncomplicated, right-sided infection; refer to AHA guidelines
- [prosthetic valve]
- Dose: 2 g IV q4h for at least 6wk; Max: 12 g/day; Info: give w/ gentamicin gram positive synergy x2wk and rifampin; refer to AHA guidelines
pneumonia, community-acquired
- [2 g IV q4h for at least 5 days]
- Info: for inpatient tx
renal dosing
- [see below]
- renal impairment: no adjustment; Info: consider decr. usual dose if concurrent renal and hepatic impairment
- HD/PD: no adjustment; no supplement; Info: consider decr. usual dose if concurrent renal and hepatic impairment
hepatic dosing
- [see below]
- hepatic impairment: not defined; Info: consider decr. usual dose if concurrent hepatic and renal impairment
Peds Dosing .
- Dosage forms: INJ
infections, bacterial
- [<4 wk old, <1200 g]
- Dose: 50 mg/kg/day IV divided q12h; Info: duration varies w/ infection type, severity
- [<1 wk old, 1200-2000 g]
- Dose: 50 mg/kg/day IV divided q12h; Info: duration varies w/ infection type, severity
- [<1 wk old, >2000 g]
- Dose: 75 mg/kg/day IV divided q8h; Info: duration varies w/ infection type, severity
- [1 wk old-1 mo, 1200-2000 g]
- Dose: 75 mg/kg/day IV divided q8h; Info: duration varies w/ infection type, severity
- [1 wk old-1 mo, >2000 g]
- Dose: 100 mg/kg/day IV divided q6h; Info: duration varies w/ infection type, severity
- [1 mo-16 yo]
- Dose: 50-100 mg/kg/day IV divided q6h if mild-mod. infection; 150-200 mg/kg/day IV divided q4-6h if severe infection; Max: 12 g/day; Info: duration varies w/ infection type, severity
endocarditis
- [native valve]
- Dose: 200 mg/kg/day IV divided q4-6h x4-6wk; Max: 12 g/day; Info: may give w/ gentamicin gram positive synergy x3-5 days; refer to AHA guidelines
- [prosthetic valve]
- Dose: 200 mg/kg/day IV divided q4-6h for at least 6wk; Max: 12 g/day; Info: give w/ gentamicin gram positive synergy x2wk and rifampin; refer to AHA guidelines
pneumonia, community-acquired
- [>3 mo]
- Dose: 150-200 mg/kg/day IV divided q4-6h x10 days; Max: 12 g/day; Info: may switch to PO regimen when possible to complete course
renal dosing
- [see below]
- renal impairment: no adjustment; Info: decr. usual divided dose by 33-50% if concurrent renal and hepatic impairment
- HD/PD: no adjustment; no supplement; Info: decr. usual divided dose by 33-50% if concurrent renal and hepatic impairment
hepatic dosing
- [see below]
- hepatic impairment: not defined; Info: consider decr. usual dose if concurrent hepatic and renal impairment