aminocaproic acid

Adult Dosing .

Dosage forms:  TAB: 500 mg, 1000 mg; SOL: 250 mg per mL; INJ: various

bleeding, hyperfibrinolysis

[4-5 g IV x1, then 1 g/h IV]

Max: 30 g/day; Alt: 5 g PO x1, then 1 g (tabs) or 1.25 g (solution) PO q1h; Info: cont. x8h or until bleeding controlled

dental bleeding, hemophilia A (off-label)

[6 g PO q6h]

Start: 6 g PO x1 immed. after surgery; Max: 30 g/day; Alt: swish/swallow 5 mL q4h after peroxide, saline rinses; Info: use x9-10 days

traumatic hyphema (off-label)

[50-100 mg/kg/dose PO q4h x5 days]

Max: 5 g/dose; 30 g/day; Info: to prevent secondary ocular hemorrhage

hereditary hemorrhagic telangiectasia (off-label)

[0.5-1 g PO bid]

Start: 1-1.5 g PO bid x1-2mo

bleeding, chronic (off-label)

[5-30 g/day PO divided q3-6h]

missed abortion (off-label)

[4-5 g IV x1, then 1 g/h IV]

Max: 30 g/day; Alt: 5 g PO x1, then 1 g (tabs) or 1.25 g (solution) PO q1h; Info: cont. x8h or until bleeding controlled

renal dosing

[see below]

renal failure: not defined, caution advised

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 500 mg, 1000 mg; SOL: 250 mg per mL; INJ: various

bleeding, hyperfibrinolysis (off-label)

[100-200 mg/kg/dose PO/IV x1, then 100 mg/kg/dose PO/IV q4-6h]

Max: 30 g/day

renal dosing

[adjust dose amount]

oliguria/ESRD: decr. usual dose by 75-88%

HD/PD: not defined

hepatic dosing

[not defined]