Katerzia

Adult Dosing .

Dosage forms:  SUSP: 1 mg per mL

HTN

[5-10 mg PO qd]

Start: 5 mg PO qd; Max: 10 mg/day; Info: start 2.5 mg PO qd in small, fragile, or elderly pts, or if used as secondary agent; may adjust dose q1-2wk

CAD

[5-10 mg PO qd]

Max: 10 mg/day; Info: for pts w/ chronic stable angina, vasospastic angina, or angiographically documented CAD; start 5 mg PO qd in elderly pts

pulmonary arterial HTN (off-label)

[15-30 mg/day PO divided qd-bid]

Start: 5 mg PO qd; Max: 30 mg/day; Info: for pts w/ positive vasoreactivity test

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[HTN]

hepatic impairment: start 2.5 mg qd; Info: titrate slowly if severe impairment

[all other indications]

hepatic impairment: start 5 mg qd; Info: titrate slowly if severe impairment

Peds Dosing .

Dosage forms:  SUSP: 1 mg per mL

HTN

[1-5 yo (off-label)]

Dose: 0.1-0.6 mg/kg/dose PO qd; Max: 5 mg/day

[6-17 yo]

Dose: 2.5-5 mg PO qd; Max: 10 mg/day

pulmonary arterial HTN (off-label)

[2.5-10 mg PO bid]

Start: 0.1 mg/kg/dose PO bid; Max: 20 mg/day; Info: for pts w/ positive vasoreactivity test

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance