Myxredlin

Adult Dosing .

Dosage forms:  INJ: 1 unit per mL

Special Note

[additional info]

Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility

diabetes mellitus, type 1

[individualize dose via IV infusion]

Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)

diabetes mellitus, type 2

[individualize dose via IV infusion]

Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)

diabetic ketoacidosis (off-label)

[individualize dose via IV infusion]

Start: 0.1 units/kg/h IV; Info: may give 0.1 units/kg/dose IV x1 if infusion delay; when blood glucose <250 mg/dL, decr. dose to 0.05 units/kg/h IV and add dextrose 5-10%; maintain blood glucose at 150-200 mg/dL until DKA resolves; start insulin SC injection >1-2h before D/C insulin IV; refer to institutional protocol

hyperglycemic hyperosmolar state (off-label)

[individualize dose via IV infusion]

Start: 0.05-0.1 units/kg/h IV; Info: when blood glucose <250 mg/dL, decr. dose to 0.05 units/kg/h IV and add dextrose 5-10%; maintain blood glucose at 200-250 mg/dL until HHS resolves; start insulin SC injection >1-2h before D/C insulin IV; refer to institutional protocol

renal dosing

[see below]

renal impairment: consider decr. usual start dose

HD/PD: consider decr. usual start dose; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ: 1 unit per mL

Special Note

[additional info]

Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility

diabetes mellitus, type 1

[individualize dose via IV infusion]

Info: refer to institutional protocol; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)

diabetes mellitus, type 2

[individualize dose via IV infusion]

Info: refer to institutional protocol; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)

diabetic ketoacidosis (off-label)

[0.05-0.1 units/kg/h IV]

Start: 1h after initial fluid tx; Info: for pts w/ marked insulin sensitivity, may decr. dose to <0.05 units/kg/h IV; add dextrose 5% when blood glucose 250-300 mg/dL or if blood glucose decr. at rate >90 mg/dL/h; maintain blood glucose at 200 mg/dL until DKA resolves; start insulin SC injection adequate interval before D/C insulin IV; refer to institutional protocol

renal dosing

[see below]

renal impairment: consider decr. usual start dose

HD/PD: consider decr. usual start dose; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised