Select a medication above to begin.
Consensi
amlodipine/ celecoxib
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: TAB: 2.5 mg/200 mg, 5 mg/200 mg, 10 mg/200 mg
hypertension and osteoarthritis
- [1 tab PO qd]
- Start: 5 mg/200 mg PO qd; Max: 10 mg/200 mg/day; Info: may adjust dose q1-2wk; use lowest effective dose, shortest effective tx duration; start 2.5 mg/200 mg PO qd in small or fragile adults, elderly pts, or if used as secondary agent; refer to individual drugs for indication-specific dosing; give w/ food if GI upset
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- Child-Pugh Class A: start 2.5 mg/200 mg qd; Child-Pugh Class B or C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.