Gloperba

Adult Dosing .

Dosage forms:  SOL: 0.6 mg per 5 mL

gout prophylaxis

[0.6 mg PO qd-bid]

Max: 1.2 mg/day; Info: wait 12h after acute gout flare tx before resuming prophylaxis

renal dosing

[see below]

eGFR 15-29: start 0.3 mg qd; eGFR <15: not defined; Info: contraindicated if concurrent renal and hepatic impairment

HD: start 0.3 mg 2x/wk; no supplement after dialysis; PD: not defined; Info: contraindicated if concurrent renal and hepatic impairment

hepatic dosing

[see below]

severe impairment: consider decr. usual dose; Info: contraindicated if concurrent hepatic and renal impairment

Peds Dosing .

Dosage forms:  SOL: 0.6 mg per 5 mL

gout prophylaxis

[>16 yo]

Dose: 0.6 mg PO qd-bid; Max: 1.2 mg/day

familial Mediterranean fever (off-label)

[4-6 yo]

Dose: 0.3-1.8 mg/day PO divided qd-bid; Max: 1.8 mg/day; Info: may adjust dose by 0.3 mg/day; use lowest effective dose

[6-12 yo]

Dose: 0.9-1.8 mg/day PO divided qd-bid; Max: 1.8 mg/day; Info: may adjust dose by 0.3 mg/day; use lowest effective dose

[>12 yo]

Dose: 1.2-2.4 mg/day PO divided qd-bid; Max: 2.4 mg/day; Info: may adjust dose by 0.3 mg/day; use lowest effective dose

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance