Wakix

Adult Dosing .

Dosage forms:  TAB: 4.45 mg, 17.8 mg

narcolepsy

[17.8-35.6 mg PO qam]

Start: 8.9 mg PO qam x1wk, then 17.8 mg PO qam x1wk, then may incr. to 35.6 mg PO qam; Max: 35.6 mg/day; Info: max 17.8 mg/day in CYP2D6 poor metabolizers

renal dosing

[see below]

eGFR 60-89: not defined, caution advised; eGFR 15-59: start 8.9 mg qd x7 days, then incr. to max 17.8 mg/day; eGFR <15: avoid use

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class B: start 8.9 mg qd x14 days, then incr. to max 17.8 mg/day; Child-Pugh Class C: contraindicated

Peds Dosing .

Dosage forms:  TAB: 4.45 mg, 17.8 mg

narcolepsy

[6 yo and older, <40 kg]

Dose: 17.8 mg PO qam; Start: 4.45 mg PO qam x1wk, then 8.9 mg PO qam x1wk, then 17.8 mg PO qam; Max: 17.8 mg/day; Info: max 8.9 mg/day in CYP2D6 poor metabolizers

[6 yo and older, >40 kg]

Dose: 17.8-35.6 mg PO qam; Start: 4.45 mg PO qam x1wk, then 8.9 mg PO qam x1wk, then 17.8 mg PO qam x1wk, then may incr. to 35.6 mg PO qam; Max: 35.6 mg/day; Info: max 17.8 mg/day in CYP2D6 poor metabolizers

renal dosing

[<40 kg]

eGFR 60-89: not defined, caution advised; eGFR <60: start 4.45 mg qd x7 days, then incr. to max 8.9 mg/day

HD/PD: not defined

[>40 kg]

eGFR 60-89: not defined, caution advised; eGFR <60: start 4.45 mg qd x7 days, then 8.9 mg qd x7 days, then may incr. to max 17.8 mg/day

HD/PD: not defined

hepatic dosing

[<40 kg]

Child-Pugh Class B: start 4.45 mg qd x14 days, then incr. to max 8.9 mg/day; Child-Pugh Class C: contraindicated

[>40 kg]

Child-Pugh Class B: start 4.45 mg qd x14 days, then 8.9 mg qd x14 days, then may incr. to max 17.8 mg/day; Child-Pugh Class C: contraindicated