Select a medication above to begin.
Drizalma Sprinkle
duloxetine
Black Box Warnings .
Suicidality
antidepressants incr. suicidality risk in peds and young adult pts in short-term studies; monitor closely for clinical worsening and suicidality; advise families and caregivers of need for close observation and communication w/ prescriber
Adult Dosing .
Dosage forms: DR CAP: 20 mg, 30 mg, 40 mg, 60 mg
major depressive disorder
- [acute tx]
- Dose: 20-30 mg PO bid or 60 mg PO qd; Max: 120 mg/day; Info: may start 30 mg PO qd x1wk if tolerability concern; doses >60 mg/day rarely more effective, may incr. ADR risk; may open cap, but do not crush/chew contents; taper dose gradually to D/C
- [maintenance tx]
- Dose: 60 mg PO qd; Max 120 mg/day: Info: doses >60 mg/day rarely more effective, may incr. ADR risk; may open cap, but do not crush/chew contents; periodically reassess need for tx; taper dose gradually to D/C
generalized anxiety disorder
- [60 mg PO qd]
- Max: 120 mg/day; Info: start 30 mg PO qd x2wk in elderly pts; may start 30 mg PO qd x1wk if tolerability concern; may incr. dose in 30 mg increments; doses >60 mg/day rarely more effective, may incr. ADR risk; may open cap, but do not crush/chew contents; taper dose gradually to D/C
neuropathic pain, diabetic
- [60 mg PO qd]
- Max: 120 mg/day; Info: consider lower start dose if tolerability concern; doses >60 mg/day rarely more effective, may incr. ADR risk; may open cap, but do not crush/chew contents; taper dose gradually to D/C
fibromyalgia
- [60 mg PO qd]
- Start: 30 mg PO qd x1wk; Max: 60 mg/day; Info: some pts may respond to 30 mg/day; may open cap, but do not crush/chew contents; taper dose gradually to D/C
musculoskeletal pain, chronic
- [60 mg PO qd]
- Start: 30 mg PO qd x1wk; Max: 60 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
renal dosing
- [neuropathic pain, diabetic]
- CrCl 30-89: consider decr. start dose, titrate slowly; CrCl <30: avoid use
- HD/PD: not defined
- [all other indications]
- CrCl <30: avoid use
- HD/PD: not defined
hepatic dosing
- [see below]
- chronic hepatic dz or cirrhosis: avoid use
Peds Dosing .
- Dosage forms: DR CAP: 20 mg, 30 mg, 40 mg, 60 mg
generalized anxiety disorder
- [7-17 yo]
- Dose: 30-60 mg PO qd; Start: 30 mg PO qd, may incr. by 30 mg/day after 2wk; Max: 120 mg/day; Info: may open cap, but do not crush/chew contents; taper dose gradually to D/C
renal dosing
- [see below]
- CrCl <30: avoid use
- HD/PD: not defined
hepatic dosing
- [see below]
- chronic hepatic dz or cirrhosis: avoid use