Select a medication above to begin.
Nayzilam
midazolam nasal
Black Box Warnings .
Risks from Concomitant Opioid Use
concomitant benzodiazepine use w/ opioids may result in profound sedation, resp. depression, coma, and death; reserve concomitant use for pts w/ inadequate alternative tx options; limit to minimum required dosage and duration; monitor pts for s/sx of resp. depression and sedation
Addiction, Abuse, and Misuse
benzodiazepines expose users to risk of abuse, misuse, and addiction, can lead to overdose or death; commonly involves concomitant use w/ other meds, alcohol, and/or illicit substances, which is assoc. w/ incr. frequency of serious adverse outcomes; assess risk for abuse, misuse, and addiction before prescribing and throughout tx
Dependence and Withdrawal Reactions
cont. benzodiazepine use may lead to clinically significant physical dependence; risk of dependence and withdrawal incr. w/ longer tx duration and higher daily dose; if used more frequently than recommended, use gradual taper to D/C as abrupt D/C or rapid dose reduction may cause acute withdrawal reactions, potentially life-threatening
Adult Dosing .
Dosage forms: SPRAY: 5 mg per unit
Special Note
- [dosing clarification]
- Info: each unit delivers 1 spray
seizures, acute repetitive
- [1 spray (5 mg) in one nostril x1]
- Max: 2 doses/single episode; 1 episode q3 days up to 5 episodes/mo; Info: may repeat dose x1 in opposite nostril after 10min
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: SPRAY: 5 mg per unit
Special Note
- [dosing clarification]
- Info: each unit delivers 1 spray
seizures, acute repetitive
- [12 yo and older]
- Dose: 1 spray (5 mg) in one nostril x1; Max: 2 doses/single episode; 1 episode q3 days up to 5 episodes/mo; Info: may repeat dose x1 in opposite nostril after 10min
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised