Brukinsa

Adult Dosing .

Dosage forms:  CAP: 80 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; consider holding tx x3-7 days before and after surgery if bleeding risk

mantle cell lymphoma, relapsed or refractory

[160 mg PO bid]

Alt: 320 mg PO qd

Waldenstrom macroglobulinemia

[160 mg PO bid]

Alt: 320 mg PO qd

marginal zone lymphoma, relapsed or refractory

[160 mg PO bid]

Alt: 320 mg PO qd; Info: for pts who have received at least one anti-CD20-based tx

CLL/SLL

[160 mg PO bid]

Alt: 320 mg PO qd

follicular lymphoma, relapsed or refractory

[160 mg PO bid]

Alt: 320 mg PO qd; Info: for pts refractory to at least 2 prior tx; use w/ obinutuzumab

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class C: 80 mg bid

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.