Vumerity

Adult Dosing .

Dosage forms:  DR CAP: 231 mg

multiple sclerosis, relapsing forms

[462 mg PO bid]

Start: 231 mg PO bid x7 days, then 462 mg PO bid; Info: for pts w/ clinically isolated syndrome, relapsing-remitting dz, and active secondary progressive dz; may temporarily decr. dose to 231 mg PO bid if not tolerated, then resume usual dose of 462 mg PO bid w/in 4wk or consider D/C if usual dose still not tolerated; see pkg insert for tx considerations based on lymphopenia; consider giving w/ aspirin 30min before dose or w/ food to reduce flushing; avoid admin. w/ high fat, high calorie meal/snack; do not open cap

renal dosing

[see below]

mod-severe impairment: avoid use

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.