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Caplyta
lumateperone
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly pts w/ dementia-related psychosis treated w/ antipsychotics
Suicidality
incr. suicidality risk in pts <24 yo in short-term studies; monitor closely for clinical worsening, suicidality, or unusual behavior changes; not approved in peds pts
Adult Dosing .
Dosage forms: CAP: 10.5 mg, 21 mg, 42 mg
schizophrenia
- [42 mg PO qd]
- Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar disorder, depressive episode
- [monotherapy]
- Dose: 42 mg PO qd; Info: for bipolar I or bipolar II disorder; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
- [valproate or lithium adjunct]
- Dose: 42 mg PO qd; Info: for bipolar I or bipolar II disorder; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class B or C: 21 mg qd
Peds Dosing .
- Dosage forms: --