Esperoct (antihemophilic factor (factor VIII, recombinant), glycopegylated-exei)

Adult Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: nonproprietary name = antihemophilic factor (factor VIII, recombinant), glycopegylated-exei

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor]

Dose: 40 unit/kg/dose IV x1; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding episode, moderate]

Dose: 40 unit/kg/dose IV x1; may repeat dose x1 after 24h; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding episode, major]

Dose: 50 unit/kg/dose IV x1; may repeat dose q24h; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding prophylaxis, minor surgery]

Dose: 50 unit/kg/dose IV x1 preop; may repeat dose q24h; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding prophylaxis, major surgery]

Dose: 50 unit/kg/dose IV x1 preop; may repeat dose q24h x1wk, then q48h until adequate wound healing; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[routine bleeding prophylaxis]

Dose: 50 units/kg/dose IV q4 days

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: nonproprietary name = antihemophilic factor (factor VIII, recombinant), glycopegylated-exei

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor, <12 yo]

Dose: 65 unit/kg/dose IV x1; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding episode, minor, 12 yo and older]

Dose: 40 unit/kg/dose IV x1; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding episode, moderate, <12 yo]

Dose: 65 unit/kg/dose IV x1; may repeat dose x1 after 24h; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding episode, moderate, 12 yo and older]

Dose: 40 unit/kg/dose IV x1; may repeat dose x1 after 24h; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding episode, major, <12 yo]

Dose: 65 unit/kg/dose IV x1; may repeat dose q24h; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding episode, major, 12 yo and older]

Dose: 50 unit/kg/dose IV x1; may repeat dose q24h; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding prophylaxis, minor surgery, <12 yo]

Dose: 65 unit/kg/dose IV x1 preop; may repeat dose q24h; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding prophylaxis, minor surgery, 12 yo and older]

Dose: 50 unit/kg/dose IV x1 preop; may repeat dose q24h; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding prophylaxis, major surgery, <12 yo]

Dose: 65 unit/kg/dose IV x1 preop; may repeat dose q24h x1wk, then q48h until adequate wound healing; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[bleeding prophylaxis, major surgery, 12 yo and older]

Dose: 50 unit/kg/dose IV x1 preop; may repeat dose q24h x1wk, then q48h until adequate wound healing; Alt: dose (units) = [wt (kg) x desired factor VIII level incr. (%) x 0.5]

[routine bleeding prophylaxis, <12 yo]

Dose: 65 units/kg/dose IV 2x/wk

[routine bleeding prophylaxis, 12 yo and older]

Dose: 50 units/kg/dose IV q4 days

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]