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amlodipine/ benazepril
generic
Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: CAP: 2.5 mg/10 mg, 5 mg/10 mg, 5 mg/20 mg, 5 mg/40 mg, 10 mg/20 mg, 10 mg/40 mg
HTN
- [1 cap PO qd]
- Start: based on prior doses of either component, may incr. dose after 1wk; Max: 10 mg/80 mg/day; Info: not for initial tx; may use if failed monotherapy w/ either drug class; start combo at lower dose of amlodipine if receiving prior max tolerable dose; start amlodipine 2.5 mg in elderly
renal dosing
- [see below]
- CrCl <30: avoid use, dose adjustment not possible w/ fixed-dose combo
- HD/PD: avoid use, dose adjustment not possible w/ fixed-dose combo
hepatic dosing
- [adjust dose amount]
- hepatic impairment: start 2.5 mg/10 mg qd
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.