Isturisa

Adult Dosing .

Dosage forms:  TAB: 1 mg, 5 mg

Cushing syndrome

[2-7 mg PO bid]

Start: 2 mg PO bid, then may incr. dose by 2-4 mg/day no more frequently than q2wk; Max: 60 mg/day; Info: for pts ineligible for or who have failed surgery; adjust dose based on tx response and urinary free cortisol levels; in pts w/ elevated cortisol levels receiving 10 mg bid, may further incr. dose by 10 mg/day no more frequently than q2wk

renal dosing

[see below]

renal impairment: no adjustment; Info: reduced urine free cortisol excretion if mod-severe renal impairment; adjust dose based on urine free cortisol levels

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class B: start 1 mg bid; Child-Pugh Class C: start 1 mg qhs

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.