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Oriahnn
elagolix/ estradiol/ norethindrone acetate and elagolix
Black Box Warnings .
Thromboembolic Disorders and Vascular Events
estrogen + progestin tx incr. thrombotic/thromboembolism risk incl. PE, DVT, stroke, and MI, esp. women at high risk for these events; contraindicated in women w/ current or past hx of thrombotic/thromboembolic disorder or if incr. risk, incl. smokers >35 yo and uncontrolled HTN
Adult Dosing .
Dosage forms: convenience pack
Special Note
- [convenience pack components]
- Info: 7-day pack contains elagolix 300 mg/estradiol 1 mg/norethindrone acetate 0.5 mg x7 and elagolix 300 mg x7
menorrhagia, uterine fibroid-assoc.
- [AM dose]
- Dose: 1 cap (elagolix/estradiol/norethindrone acetate) PO qam; Start: after pregnancy excluded or w/in 7 days from onset of menses; Max: 24mo; Info: for premenopausal pts
- [PM dose]
- Dose: 1 cap (elagolix) PO qpm; Start: after pregnancy excluded or w/in 7 days from onset of menses; Max: 24mo; Info: for premenopausal pts
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment/dz: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.