Solu-Medrol

Adult Dosing .

Dosage forms:  INJ

corticosteroid-responsive conditions

[10-250 mg IV/IM q4h]

Info: dose, frequency varies by condition; taper dose gradually to D/C if high-dose or long-term use

aplastic anemia

[1 mg/kg/dose IV qd x4 days]

lupus nephritis

[1 g IV qd x3 days]

spinal cord injury

[30 mg/kg/dose IV x1, then 5.4 mg/kg/h IV x23h]

asthma, acute

[60-80 mg IV qd x5-7 days]

Info: switch to PO regimen ASAP to complete course

adrenal insufficiency, acute

[1 mg/kg/day IV divided q6h x24-48h]

Alt: 1 mg/kg/day IV infusion x24-48h

multiple sclerosis, acute exacerbation

[1 g IV qd x3-5 days]

PCP, adjunct tx (off-label)

[30 mg IV bid x5 days, then 30 mg IV qd x5 days, then 15 mg IV qd x11 days]

Start: w/in 72h of antimicrobial tx

community-acquired pneumonia, severe bacterial (off-label)

[0.5 mg/kg/dose IV q12h x7 days]

Start: w/in 36h of admission if C-reactive protein >150 mg/dL; Alt: 40 mg IV x1, then 40 mg/day IV infusion or divided bid x1wk, then 20 mg/day IV infusion or divided bid x1wk, then 12 mg/day IV infusion or divided bid x3 days, then 4 mg/day IV infusion or divided bid x3 days; Info: may switch to equivalent total daily dose PO divided bid to complete course

ARDS (off-label)

[early]

Dose: 1 mg/kg/dose IV x1, then 1 mg/kg/day IV infusion x2wk or until extubation, then 0.5 mg/kg/day IV infusion x1wk, then 0.25 mg/kg/day IV infusion x4 days, then 0.125 mg/kg/day IV infusion x3 days; Start: w/in 72h of onset

[unresolving]

Dose: 2 mg/kg/dose IV x1, then 2 mg/kg/day IV divided q6h x2wk or until extubation, then 1 mg/kg/day IV divided q6h x1wk, then 0.5 mg/kg/day IV divided q6h x1wk, then 0.25 mg/kg/day IV divided q6h x2 days, then 0.125 mg/kg/day IV divided q6h x2 days; Start: w/in 7-21 days of onset

renal dosing

[see below]

renal impairment: no adjustment; Info: caution advised, may cause sodium retention

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

corticosteroid-responsive conditions

[0.5-1.7 mg/kg/day IV/IM divided q6-12h]

Info: dose, frequency varies by condition; taper dose gradually to D/C if high-dose or long-term use

asthma, acute

[<6 yo]

Dose: 1-2 mg/kg/day IV/IM divided q12-24h x3-10 days; Max: 60 mg/day; Alt: start 1 mg/kg/dose IV q6h on day 1, then switch to PO prednisolone to complete 3-5 day course; taper gradually to D/C if long-term use

[6-11 yo]

Dose: 1-2 mg/kg/day IV/IM divided q12-24h x3-10 days; Max: 60 mg/day; Info: switch to PO regimen ASAP to complete course; taper gradually to D/C if long-term use

[12 yo and older]

Dose: 40-80 mg/day IV/IM divided q12-24h x3-10 days; Info: switch to PO regimen ASAP to complete course; taper gradually to D/C if long-term use

lupus nephritis

[30 mg/kg/dose IV qod x6 doses]

spinal cord injury

[30 mg/kg/dose IV x1, then 5.4 mg/kg/h IV x23h]

PCP, adjunct tx (off-label)

[children]

Dose: 1 mg/kg/dose IV q6h x7 days, then 1 mg/kg/dose IV q12h x2 days, then 0.5 mg/kg/dose IV q12h x2 days, then 1 mg/kg/dose IV qd x5 days; Start: w/in 72h of antimicrobial tx

[adolescents]

Dose: 30 mg IV bid x5 days, then 30 mg IV qd x5 days, then 15 mg IV qd x11 days; Start: w/in 72h of antimicrobial tx

renal dosing

[see below]

renal impairment: no adjustment; Info: caution advised, may cause sodium retention

HD/PD: not defined

hepatic dosing

[not defined]