Tivicay PD

Adult Dosing .

Dosage forms:  DISPERSE TAB: 5 mg

Special Note

[formulation clarification]

Info: not interchangeable w/ dolutegravir tabs; do not substitute on a mg to mg basis

HIV infection (off-label)

[30 mg PO qd]

Info: for tx-naive or tx-experienced INSTI-naive pts; incr. dose to 30 mg PO bid if also receiving carbamazepine, efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, or rifampin; do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Dosage forms:  DISPERSE TAB: 5 mg

Special Note

[formulation clarification]

Info: not interchangeable w/ dolutegravir tabs; do not substitute on a mg to mg basis

HIV infection

[4 wk old and older, 3-5 kg]

Dose: 5 mg PO qd; Info: for tx-naive or tx-experienced INSTI-naive pts; incr. dose to 5 mg PO bid if also receiving carbamazepine, efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, or rifampin; do not cut/crush/chew tab

[4 wk old and older, 6-9 kg]

Dose: 15 mg PO qd; Info: for tx-naive or tx-experienced INSTI-naive pts; incr. dose to 15 mg PO bid if also receiving carbamazepine, efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, or rifampin; do not cut/crush/chew tab

[4 wk old and older, 10-13 kg]

Dose: 20 mg PO qd; Info: for tx-naive or tx-experienced INSTI-naive pts; incr. dose to 20 mg PO bid if also receiving carbamazepine, efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, or rifampin; do not cut/crush/chew tab

[4 wk old and older, 14-19 kg]

Dose: 25 mg PO qd; Info: for tx-naive or tx-experienced INSTI-naive pts; incr. dose to 25 mg PO bid if also receiving carbamazepine, efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, or rifampin; do not cut/crush/chew tab

[4 wk old and older, >20 kg]

Dose: 30 mg PO qd; Info: for tx-naive or tx-experienced INSTI-naive pts; incr. dose to 30 mg PO bid if also receiving carbamazepine, efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, or rifampin; do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined