Mestinon

Adult Dosing .

Dosage forms:  TAB: 60 mg; ER TAB: 180 mg; SOL: 60 mg per 5 mL

myasthenia gravis

[60-120 mg PO q3-8h]

Start: 60 mg PO q8h; Max: 1500 mg/day; Alt: 180-540 mg ER PO qd-bid, space doses at least 6h apart

renal dosing

[adjust dose amount]

CrCl 51-89: decr. usual dose by 50%; CrCl 10-50: decr. usual dose by 65%; CrCl <10: decr. usual dose by 80%

HD: decr. usual dose by 80%; no supplement after dialysis; PD: decr. usual dose by 80%; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 60 mg; SOL: 60 mg per 5 mL

myasthenia gravis (off-label)

[neonates]

Dose: 5 mg PO q4-6h

[children]

Dose: 7 mg/kg/day PO divided in 5-6 doses

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]