colchicine

Adult Dosing .

Dosage forms:  CAP: 0.6 mg; TAB: 0.6 mg

gout, acute

[1.2 mg PO x1, then 0.6 mg PO 1h later x1]

Max: 1.8 mg total dose/tx course; Info: do not repeat x3 days

gout prophylaxis

[0.6 mg PO qd-bid]

Max: 1.2 mg/day; Info: wait 12h after acute gout flare tx before resuming prophylaxis

familial Mediterranean fever

[1.2-2.4 mg/day PO divided qd-bid]

Max: 2.4 mg/day; Info: may adjust dose by 0.3 mg/day; use lowest effective dose

Behcet dz (off-label)

[0.6 mg PO bid-tid]

Info: use lowest effective dose

pericarditis, recurrent (off-label)

[0.6 mg PO qd-bid]

Info: use lowest effective dose

renal dosing

[gout, acute]

CrCl <30: repeat tx course no more frequently than q2wk; Info: consider alternative if repeated courses; avoid use if already on colchicine for gout prophylaxis

HD: 0.6 mg x1, repeat tx course no more frequently than q2wk; no supplement after dialysis; PD: not defined; Info: consider alternative if repeated courses; avoid use if already on colchicine for gout prophylaxis

[gout prophylaxis]

CrCl <30: start 0.3 mg qd; Info: contraindicated if concurrent renal and hepatic impairment

HD: start 0.3 mg 2x/wk; no supplement after dialysis; PD: not defined; Info: contraindicated if concurrent renal and hepatic impairment

[familial Mediterranean fever]

CrCl 30-80: consider decr. usual dose; CrCl <30: start 0.3 mg qd

HD: start 0.3 mg qd; no supplement after dialysis; PD: not defined

[off-label uses]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[gout, acute]

severe impairment: repeat tx course no more frequently than q2wk; Info: consider alternative if repeated courses; avoid use if hepatic impairment and also on colchicine for gout prophylaxis

[gout prophylaxis]

severe impairment: consider decr. usual dose; Info: contraindicated if concurrent hepatic and renal impairment

[familial Mediterranean fever]

severe impairment: consider decr. usual dose

[off-label uses]

hepatic impairment: not defined

Peds Dosing .

Dosage forms:  CAP: 0.6 mg; TAB: 0.6 mg

gout prophylaxis

[>16 yo]

Dose: 0.6 mg PO qd-bid; Max: 1.2 mg/day

familial Mediterranean fever

[4-6 yo]

Dose: 0.3-1.8 mg/day PO divided qd-bid; Max: 1.8 mg/day; Info: may adjust dose by 0.3 mg/day; use lowest effective dose

[6-12 yo]

Dose: 0.9-1.8 mg/day PO divided qd-bid; Max: 1.8 mg/day; Info: may adjust dose by 0.3 mg/day; use lowest effective dose

[>12 yo]

Dose: 1.2-2.4 mg/day PO divided qd-bid; Max: 2.4 mg/day; Info: may adjust dose by 0.3 mg/day; use lowest effective dose

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance