Minocin

Adult Dosing .

Dosage forms:  INJ

Dosage Forms Discontinued in US

[50 mg, 75 mg, 100 mg caps not avail. as brand; see generic]

infections, bacterial

[100 mg PO/IV q12h]

Start: 200 mg PO/IV x1; Max: 400 mg/24h; Alt: start 100-200 mg PO x1, then 50 mg PO qid; Info: duration varies w/ infection type, severity; give cap w/ adequate fluid to decr. esophageal irritation/ulceration

severe acne vulgaris, adjunct tx

[50-100 mg PO qd]

Start: 50-100 mg PO bid x2-3mo; Info: give w/ adequate fluid to decr. esophageal irritation/ulceration

leprosy (Hansen dz), multibacillary (off-label)

[pts who cannot take clofazimine]

Dose: 100 mg PO qd x12mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 12mo in refractory cases

[pts who cannot take rifampin]

Dose: 100 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 24mo in refractory cases

leprosy (Hansen dz), paucibacillary (off-label)

[pts who cannot take rifampin]

Dose: 100 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 24mo in refractory cases

renal dosing

[see below]

renal impairment: decr. usual dose and/or frequency, amount not defined, max 200 mg/24h

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Dosage Forms Discontinued in US

[50 mg, 75 mg, 100 mg caps not avail. as brand; see generic]

infections, bacterial

[>8 yo]

Dose: 2 mg/kg/dose PO/IV q12h; Start: 4 mg/kg/dose PO/IV x1; Max: 200 mg/24h; Info: duration varies w/ infection type, severity; give cap w/ adequate fluid to decr. esophageal irritation/ulceration

severe acne vulgaris, adjunct tx

[>8 yo]

Dose: 50-100 mg PO qd; Start: 50-100 mg PO bid x2-3mo; Info: give w/ adequate fluid to decr. esophageal irritation/ulceration

leprosy (Hansen dz), multibacillary (off-label)

[15 yo and older, pts who cannot take clofazimine]

Dose: 100 mg PO qd x12mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 12mo in refractory cases

[15 yo and older, pts who cannot take rifampin]

Dose: 100 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 24mo in refractory cases

leprosy (Hansen dz), paucibacillary (off-label)

[15 yo and older, pts who cannot take rifampin]

Dose: 100 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; give w/ adequate fluid to decr. esophageal irritation/ulceration; may continue tx beyond 24mo in refractory cases

renal dosing

[see below]

renal impairment: decr. usual dose and/or frequency, amount not defined, max 200 mg/24h

HD/PD: not defined

hepatic dosing

[not defined]