Arcalyst

Adult Dosing .

Dosage forms:  INJ: 80 mg per mL

cryopyrin-assoc. periodic syndromes

[160 mg SC qwk starting wk 2]

Start: 320 mg SC x1

interleukin-1 receptor antagonist deficiency, maintenance tx

[320 mg SC qwk]

Max: 320 mg/dose up to 1 dose/wk

pericarditis, recurrent

[160 mg SC qwk starting wk 2]

Start: 320 mg SC x1; Info: for initial tx and recurrence risk reduction

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ: 80 mg per mL

cryopyrin-assoc. periodic syndromes

[12-17 yo]

Dose: 2.2 mg/kg/dose SC qwk starting wk 2; Start: 4.4 mg/kg/dose SC x1; Max: 320 mg/dose for start dose, 160 mg/dose for maint. dose

interleukin-1 receptor antagonist deficiency, maintenance tx

[>10 kg]

Dose: 4.4 mg/kg/dose SC qwk; Max: 320 mg/dose

pericarditis, recurrent

[12-17 yo]

Dose: 2.2 mg/kg/dose SC qwk starting wk 2; Start: 4.4 mg/kg/dose SC x1; Max: 320 mg/dose for start dose, 160 mg/dose for maint. dose; Info: for initial tx and recurrence risk reduction

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]