pramipexole

Adult Dosing .

Dosage forms:  TAB: 0.125 mg, 0.25 mg, 0.5 mg, 0.75 mg, 1 mg, 1.5 mg; ER TAB: 0.375 mg, 0.75 mg, 1.5 mg, 2.25 mg, 3 mg, 3.75 mg, 4.5 mg

Parkinson dz

[immediate-release form]

Dose: 0.5-1.5 mg PO tid; Start: 0.125 mg PO tid x7 days, then 0.25 mg PO tid x7 days, then may incr. by 0.75 mg/day q7 days; Max: 4.5 mg/day; Info: taper dose by 0.75 mg/day to 0.25 mg PO tid, then taper dose by 0.375 mg/day to D/C

[extended-release form]

Dose: 0.375-4.5 mg ER PO qd; Start: 0.375 mg ER PO qd x5-7 days, then 0.75 mg ER PO qd x5-7 days, then may incr. by 0.75 mg/day q5-7 days; Max: 4.5 mg/day ER; Info: switch from IR to ER overnight at same daily dose; do not cut/crush/chew ER tab; taper dose by 0.75 mg/day to 0.75 mg PO qd, then taper dose by 0.375 mg/day to D/C

restless legs syndrome, mod-severe primary

[0.125-0.5 mg PO qpm]

Start: 0.125 mg PO qpm x4-7 days, then may incr. to 0.25 mg PO qpm x4-7 days, then may incr. to 0.5 mg PO qpm; Max: 0.5 mg/day; Info: give 2-3h before bedtime; taper dose gradually to D/C

sleep-related eating disorder (off-label)

[0.125-1.5 mg PO qhs]

Start: 0.125 mg PO qhs, then may titrate slowly; Info: taper dose gradually to D/C

rapid eye movement sleep behavior disorder (off-label)

[0.125-1.5 mg PO qhs]

Start: 0.125 mg PO qhs, then may titrate slowly; Info: taper dose gradually to D/C

renal dosing

[parkinsonism, immediate-release form]

CrCl 30-50: start 0.125 mg bid, max 0.75 mg tid; CrCl 15-30: start 0.125 mg qd, max 1.5 mg qd; CrCl <15: not defined

HD/PD: not defined

[parkinsonism, extended-release form]

CrCl 30-50: start 0.375 mg ER qod x7 days, then 0.375 mg ER qd x7 days, then may incr. by 0.375 mg/day q7 days, max 2.25 mg/day ER; CrCl <30: not defined

HD/PD: not defined

[all other indications]

CrCl 20-60: start 0.125 mg qpm x14 days, then may incr. to 0.25 mg qpm x14 days, then may incr. to 0.5 mg qpm; CrCl <20: not defined

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  TAB: 0.125 mg, 0.25 mg, 0.5 mg, 0.75 mg, 1 mg, 1.5 mg

restless legs syndrome (off-label)

[5 yo and older]

Dose: 0.125-0.375 mg PO qhs; Start: 0.125 mg PO qhs, then may titrate slowly; Info: taper dose gradually to D/C

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance