Comirnaty

Adult Dosing .

Dosage forms:  INJ

Special Note

[prescribing info]

Info: see Pfizer-BioNTech COVID-19 Vaccine for Emergency Use Authorization in pts 6 mo-11 yo

COVID-19 prevention

[immunocompetent or mildly immunocompromised pts, <65 yo]

Dose: 0.3 mL IM x1 dose; Info: give at least 8wk after last COVID-19 vaccine dose if previously vaccinated; search 'immunization' for epocrates Adult Immunization decision tool incl. links to CDC/ACIP schedules

[immunocompetent or mildly immunocompromised pts, 65 yo and older]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Info: give at least 8wk after last COVID-19 vaccine dose if previously vaccinated; search 'immunization' for epocrates Adult Immunization decision tool incl. links to CDC/ACIP schedules

[moderately-severely immunocompromised pts, not previously vaccinated]

Dose: 0.3 mL IM x2 doses 3wk apart, then 0.3 mL IM x1 dose at least 4wk later, then 0.3 mL IM x1 dose at least 6mo later; Info: may give additional dose at least 2mo after last dose and consider further doses on case-by-case basis; search 'immunization' for epocrates Adult Immunization decision tool incl. links to CDC/ACIP schedules

[moderately-severely immunocompromised pts, previously received 1 Pfizer-BioNTech vaccine dose]

Dose: 0.3 mL IM x2 doses at least 4wk apart, then 0.3 mL IM x1 dose at least 6mo later; Start: 3wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses on case-by-case basis; search 'immunization' for epocrates Adult Immunization decision tool incl. links to CDC/ACIP schedules

[moderately-severely immunocompromised pts, previously received 2 Pfizer-BioNTech vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 4wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses on case-by-case basis; search 'immunization' for epocrates Adult Immunization decision tool incl. links to CDC/ACIP schedules

[moderately-severely immunocompromised pts, previously received 3 or more mRNA vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 8wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses on case-by-case basis; search 'immunization' for epocrates Adult Immunization decision tool incl. links to CDC/ACIP schedules

[moderately-severely immunocompromised pts, previously received 2 or more Novavax vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 8wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses on case-by-case basis; search 'immunization' for epocrates Adult Immunization decision tool incl. links to CDC/ACIP schedules

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

Special Note

[prescribing info]

Info: see Pfizer-BioNTech COVID-19 Vaccine for Emergency Use Authorization in pts 6 mo-11 yo

COVID-19 prevention

[12 yo and older, immunocompetent or mildly immunocompromised pts]

Dose: 0.3 mL IM x1 dose; Info: give at least 8wk after last COVID-19 vaccine dose if previously vaccinated; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules

[12 yo and older, moderately-severely immunocompromised pts, not previously vaccinated]

Dose: 0.3 mL IM x2 doses 3wk apart, then 0.3 mL IM x1 dose at least 4wk later, then 0.3 mL IM x1 dose at least 6mo later; Info: may give additional dose at least 2mo after last dose and consider further doses on case-by-case basis; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules

[12 yo and older, moderately-severely immunocompromised pts, previously received 1 Pfizer-BioNTech vaccine dose]

Dose: 0.3 mL IM x2 doses at least 4wk apart, then 0.3 mL IM x1 dose at least 6mo later; Start: 3wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses on case-by-case basis; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules

[12 yo and older, moderately-severely immunocompromised pts, previously received 2 Pfizer-BioNTech vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 4wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses on case-by-case basis; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules

[12 yo and older, moderately-severely immunocompromised pts, previously received 3 or more mRNA vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 8wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses on case-by-case basis; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules

[12 yo and older, moderately-severely immunocompromised pts, previously received 2 or more Novavax vaccine doses]

Dose: 0.3 mL IM x2 doses at least 6mo apart; Start: at least 8wk after last dose; Info: may give additional dose at least 2mo after last dose and consider further doses on case-by-case basis; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[no adjustment]