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Lupkynis
voclosporin
Black Box Warnings .
Malignancies and Serious Infections
incr. risk of serious infections and malignancies in pts receiving immunosuppressants may lead to hospitalization or death
Adult Dosing .
Dosage forms: CAP: 7.9 mg
lupus nephritis
- [23.7 mg PO bid]
- Max: 23.7 mg bid; Info: give w/ mycophenolate mofetil and corticosteroids; adjust dose based on eGFR (see pgk insert); give 1h before or 2h after meals; do not open cap; consider D/C if no benefit by 24wk
renal dosing
- [see below]
- CrCl <30: 15.8 mg bid, max 15.8 mg bid; ESRD: not defined; Info: weigh risk/benefit if baseline eGFR <45; adjust dose based on eGFR (see pkg insert)
- HD/PD: not defined; Info: weigh risk/benefit if baseline eGFR <45
hepatic dosing
- [see below]
- Child-Pugh Class A or B: 15.8 mg bid, max 15.8 mg bid; Child-Pugh Class C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.