Mycobutin

Adult Dosing .

Dosage forms:  CAP: 150 mg

MAC prophylaxis, primary

[300 mg PO qd]

Alt: 150 mg PO bid; Info: not 1st-line agent; give w/ food

MAC prophylaxis, secondary

[300 mg PO qd]

Alt: 150 mg PO bid; Info: part of multi-drug regimen; give w/ food

MAC tx, disseminated (off-label)

[300 mg PO qd]

Alt: 150 mg PO bid; Info: part of multi-drug regimen; give w/ food

tuberculosis, active (off-label)

[5 mg/kg/dose PO qd for at least 6mo]

Max: 300 mg/dose; Alt: 5 mg/kg/dose PO 5x/wk for at least 6mo if directly observed tx; Info: part of multi-drug regimen; give w/ food; duration varies by infection site/severity

tuberculosis, latent (off-label)

[5-10 mg/kg/dose PO qd x4mo]

Max: 300 mg/dose; Info: not 1st-line agent; give w/ food

H. pylori infection (off-label)

[300 mg PO divided qd-bid x14 days]

Info: not 1st-line tx; part of multi-drug regimen; give w/ food; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

renal dosing

[adjust dose amount]

CrCl <30: decr. usual dose by 50%

HD/PD: not defined

hepatic dosing

[see below]

mild impairment: no adjustment; moderate-severe impairment: not defined

Peds Dosing .

Dosage forms:  CAP: 150 mg

MAC prophylaxis, primary (off-label)

[<6 yo]

Dose: 5 mg/kg/dose PO qd; Max: 300 mg/day; Info: give w/ food

[6 yo and older]

Dose: 300 mg PO qd; Alt: 150 mg PO bid; Info: not 1st-line agent; give w/ food

MAC prophylaxis, secondary (off-label)

[1 mo-12 yo]

Dose: 5 mg/kg/dose PO qd; Max: 300 mg/day; Info: part of multi-drug regimen; give w/ food

[13 yo and older]

Dose: 300 mg PO qd; Alt: 150 mg PO bid; Info: part of multi-drug regimen; give w/ food

MAC tx, disseminated (off-label)

[2-12 yo]

Dose: 10-20 mg/kg/day PO divided qd-tid; Max: 300 mg/day; Info: part of multi-drug regimen; give w/ food

[13 yo and older]

Dose: 300 mg PO qd; Alt: 150 mg PO bid; Info: part of multi-drug regimen; give w/ food

tuberculosis, active (off-label)

[5 mg/kg/dose PO qd for at least 6mo]

Max: 300 mg/dose; Alt: 5 mg/kg/dose PO 5x/wk for at least 6mo if directly observed tx; Info: part of multi-drug regimen; give w/ food; duration varies by infection site/severity

renal dosing

[adjust dose amount]

CrCl <30: decr. usual dose by 50%

HD/PD: not defined

hepatic dosing

[see below]

mild impairment: no adjustment; moderate-severe impairment: not defined