S-adenosyl-L-methionine

Reported Doses

Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely

Effectiveness Ratings

[see Herb & Supplement Effectiveness Rating Definitions table]

ADHD

[Insufficient Evidence]

Dose: 400-800 mg PO tid

alcoholic liver dz

[Insufficient Evidence]

Dose: 400 mg PO tid

cholestasis

[Possibly Effective (PO route)]

Dose: 1000-1600 mg/day PO divided qd-bid

[Possibly Effective (IV route)]

Dose: 500 mg IV bid x2wk, then 500 mg PO bid; Alt: 800 mg IV qd x2-3wk, then 1600 mg PO qd

depression

[Possibly Effective (PO route)]

Dose: 400-800 mg PO bid; Alt: 1600-3200 mg PO qd; Info: used w/ or w/o conventional tx

[Possibly Effective (IM route)]

Dose: 200-400 mg IM qd

[Possibly Effective (IV route)]

Dose: 200-400 mg IV qd

fatigue, CA-related

[Insufficient Evidence]

Dose: 400 mg PO bid

fibromyalgia

[Insufficient Evidence (PO route)]

Dose: 400 mg PO bid

[Insufficient Evidence (IM route)]

Dose: 200 mg IM qd; Alt: 200 mg IM qd plus 200 mg PO bid

[Insufficient Evidence (IV route)]

Dose: 400 mg IV qd

Gilbert syndrome

[Insufficient Evidence (PO route)]

Dose: 1200 mg PO qd

[Insufficient Evidence (IV route)]

Dose: 200-800 mg IV qd

hepatic cirrhosis

[Insufficient Evidence (PO route)]

Dose: 600 mg PO qd

[Insufficient Evidence (IV route)]

Dose: 600 mg IV bid x3 days, then 400 mg PO tid; Alt: 500-800 mg/day IV divided qd-bid; 15 mg IV qid

hepatitis C

[Insufficient Evidence]

Dose: 1600 mg PO qd; Alt: 400 mg PO tid; Info: used w/ conventional tx

osteoarthritis

[Likely Effective (PO route)]

Dose: 600-1200 mg/day PO divided qd-tid; Alt: 400 mg PO tid x1wk, then 400 mg PO bid x1wk, then 400 mg PO qd; 600 mg PO qd x2wk, then 400 mg PO qd

[Likely Effective (IV route)]

Dose: 400 mg IV qd x5 days, then 200 mg PO tid

schizophrenia

[Insufficient Evidence]

Dose: 400 mg PO bid; Start: 200 mg PO bid x1wk

sexual dysfxn, antidepressant-induced

[Insufficient Evidence]

Dose: 800 mg PO bid; Start: 400 mg PO bid x2wk