By vgreene, 7 May, 2020 Proposed mechanism: reduces inflammatory response by inhibiting IL-6 receptors or binding to sigma-1 receptors
By switaschek, 6 May, 2020 Refer complex tx-refractory GAD to specialty care per NICE;3 refer if antipsychotics used, per NICE, WFSBP3,5
By switaschek, 6 May, 2020 Can consider alternative med, biologic tx (rTMS) or yoga/exercise/meditation in lieu of 3rd-line med, per ADAC1
By switaschek, 6 May, 2020 Consider adding buspirone (2nd-line) or antispychotics (3rd-line) to 1st-line agents, per ADAC1
By switaschek, 6 May, 2020 Exhaust all 1st-line pharmaco-tx before considering 2nd-/3rd-line agents1,3-5
By vgreene, 6 May, 2020 Proposed mechanism: reduces inflammatory response via replenishment of glutathione and reduction of proinflammatory cytokines; supports host defenses and protects host cells against oxidative stress