By vgreene, 13 April, 2020 Potential drug interactions: CYP1A2 inhibitors/inducers,12,13 nifedipine,14 warfarin15
By vgreene, 13 April, 2020 HA, dizziness, agitation, drowsiness, eneuresis, sleepiness,10 sleep disturbance, disorientation, bad dreams, nausea, abdominal cramps11
By vgreene, 13 April, 2020 Cytokine storm hypothesis: Observed ↓TNF-α, IL-6 in melatonin supplement users,7 anti-oxidant effects proposed to ↓excessive immune up-regulation “cytokine storm” linked to severe COVID-192
By vgreene, 13 April, 2020 Antiviral hypothesis: Melatonin could indirectly affect ACE2 expression,6 which is involved in SARS-CoV-2 cell entry
By vgreene, 13 April, 2020 Proposed adjuvant COVID-19 tx2 based on anti-inflammatory, anti-oxidant effects;3 immunity booster via sleep adequacy;4 ↑COVID severity in older pts, older people have lower melatonin3,5
By vgreene, 13 April, 2020 There’s no scientific evidence that melatonin supplements or any alternative remedy is effective for COVID-19 prevention/tx1
By vgreene, 10 April, 2020 FDA Policy for Temporary Use of Portable Cryogenic Oxygen and Nitrogen Containers