By vgreene, 10 April, 2020 Hydroxychloroquine vs Azithromycin for Hospitalized Patients With Suspected or Confirmed COVID-10 (HAHPS); NCT04329832
By vgreene, 9 April, 2020 See cholecalciferol (vitamin D3), ergocalciferol (vitamin D2), adverse events and drug interaction check in epocrates
By vgreene, 9 April, 2020 Vit D toxicity: anorexia, ↓weight, polyuria, cardiac arrhythmias, vascular/tissue calcification (incl kidney damage). Calcium + vit D in postmenopausal women linked to 17% ↑kidney stones. Tolerable upper-intake levels vary by age (eg, 4,000 IU/d
By vgreene, 9 April, 2020 Critical illness. Mortality, LOS not better w/ high-dose vit D3 (540,000 IU PO/NGT x1 then 90,000 IU qmo x5mo) vs placebo in D-deficient pts in RCT (N=475 adult white ICU pts w/ D ≤20 ng/mL); however, ↓hospital mortality (not 6-mo mortality) noted in
By vgreene, 9 April, 2020 Flu in children. Vit D3 1200 IU/day PO in winter linked to ↓influenza A vs placebo (RR, 0.58) in RCT (N=334 school children)14