AAP

AAP 2025: Meta-analysis confirms safety, effectiveness of COVID-19 vaccination during pregnancy

September 29, 2025

A comprehensive meta-analysis presented at the American Academy of Pediatrics (AAP) 2025 National Conference reviewed data from over 1.25 million pregnant individuals across 23 meta-analyses and 200+ studies. Findings show that COVID-19 vaccination during pregnancy is both safe and beneficial for maternal and neonatal outcomes. Vaccinated individuals had a 58% lower risk of COVID-19 infection and significantly reduced risks of adverse birth outcomes, including:

• 8% lower risk of preterm birth before 37 weeks
• 34% lower risk of preterm birth before 28 weeks
• 25% lower risk of stillbirth
• 9% lower risk of NICU admission
• 17% lower risk of congenital anomalies

Importantly, no increased risks were observed for maternal hospitalization, ICU admission, gestational diabetes, hypertension, or pre-eclampsia. These findings support the safety and efficacy of COVID-19 vaccination during pregnancy and may help guide shared decision-making between patients and providers

Source:

(2025, September 26). American Academy of Pediatrics. Meta-analysis: COVID-19 vaccination during pregnancy is safe and beneficial for mother and infant. [News release]. https://www.aap.org/en/news-room/news-releases/aap/2025/meta-analysis-covid-19-vaccination-during-pregnancy-is-safe-and-beneficial-for-mother-and-infant/