ASA

ASA 2024: Ibuprofen may play role in minimizing postoperative delirium

October 22, 2024

Non-salicylate NSAIDs, such as ibuprofen, may significantly reduce the risk of postoperative delirium, according to a recent study presented at the ANESTHESIOLOGY 2024 annual meeting. Researchers analyzed medical records from 2014 to 2023 and categorized patients by age (18-64 and ≥65 years) and the medications they received (acetaminophen, salicylate NSAIDs, or non-salicylate NSAIDs). They then compared rates of delirium seven days post surgery.

In both age groups, use of non-salicylate NSAIDs was associated with lower risk of postoperative delirium compared with acetaminophen and salicylate NSAIDs. For patients ages 18 to 64 years, non-salicylate NSAID recipients had a 22% lower risk of postoperative delirium compared with acetaminophen recipients and a 70% lower risk than salicylate NSAID recipients. For those ≥65 years, non-salicylate NSAID use was associated with a 33% lower risk compared with acetaminophen and a 45% lower risk compared with salicylate NSAIDs.

Source:

American Society of Anesthesiologists. (2024, October 20). Ibuprofen and Other NSAIDs May Reduce the Risk of Postoperative Delirium. https://www.asahq.org/about-asa/newsroom/news-releases/2024/10/ibuprofen-and-other-nsaids-may-reduce-the-risk-of-postoperative-delirium