Clin Infect Dis

Can RSV and flu vaccines be given together?

August 9, 2024

Co-administration of FLU-aQIV and RSVPreF3 OA in individuals 65 and older had acceptable reactogenicity and safety profiles, according to results from a phase 3 trial. There was no clinically relevant interference with the immune responses to either vaccine, suggesting that the vaccines can be administered together without compromising effectiveness.

• The open-label trial randomized 1,045 participants to receive the vaccines either concomitantly (Co-Ad group, n = 523) or sequentially, one month apart (control group, n = 522).
• Non-inferiority was demonstrated for the A/Victoria(H1N1), B/Victoria, and B/Yamagata influenza strains and RSV-A neutralization titers. However, for the A/Darwin(H3N2) HI titers, non-inferiority wasn't initially demonstrated. A post-hoc assessment using a microneutralization assay suggested an adequate immune response to A/Darwin(H3N2) following co-administration. RSV-B neutralization titers were comparable between groups.
• Adverse events were mostly mild or moderate and transient, and serious adverse event rates were balanced between groups.

Source:

Clark R, et al. (2024, August 5). Clin Infect Dis. Safety and Immunogenicity of Respiratory Syncytial Virus Prefusion F Protein Vaccine when Co-administered with Adjuvanted Seasonal Quadrivalent Influenza Vaccine in Older Adults: A Phase 3 Randomized Trial. https://pubmed.ncbi.nlm.nih.gov/39099085/