Chronic Obstr Pulm Dis

Digital inhaler data may predict COPD flare-ups weeks in advance

July 3, 2025

Study details: This phase 4, open-label, 3-month pilot study enrolled 40 patients with moderate to severe COPD and a history of exacerbations. Participants used the ProAir Digihaler, which recorded inhalation parameters and medication use. The study aimed to assess whether changes in these digital metrics could signal impending acute exacerbations of COPD (AECOPDs).

Results: In the two weeks preceding an AECOPD, patients showed significant declines in inhalation volume and duration, alongside increased inhaler use. These changes were consistent across multiple exacerbation events, suggesting a reproducible physiologic pattern detectable via the digital inhaler.

Clinical impact: Digital inhalers may offer clinicians a novel, non-invasive tool for early detection of AECOPDs, enabling timely interventions that could reduce hospitalizations, slow disease progression, and improve patient outcomes.

Source:

Drummond MB, et al. (2025, May 27). Chronic Obstr Pulm Dis. Use of a Digital Inhaler to Assess COPD Disease Variability and Identify Impending Acute COPD Exacerbations: A Pilot Study. https://pubmed.ncbi.nlm.nih.gov/40459430/