JAMA Netw Open

Do multivitamins impact mortality risk?

July 3, 2024

In this cohort study of U.S. adults, multivitamin (MV) use wasn't associated with a mortality benefit. Still, many U.S. adults report using MVs to maintain or improve health.

• This cohort study used data from three prospective cohort studies in the U.S. that looked at baseline MV use, follow-up MV use of up to 27 years, and characterization of possible confounders. The main outcome measured was mortality.
• Among 390,124 participants (median age, 61.5 years; 55.4% male), 164,762 deaths occurred during follow-up; 40.9% were never smokers, and 40.3% were college educated. Among daily MV users, 49.3% and 42.0% were female and college educated, compared with 39.3% and 37.9% among nonusers, respectively. In contrast, 11.0% of daily users, vs. 13.0% of nonusers, were current smokers.
• MV use wasn't associated with lower all-cause mortality risk in the first (multivariable-adjusted hazard ratio [HR], 1.04; 95% CI, 1.02-1.07) or second (multivariable-adjusted HR, 1.04; 95% CI, 0.99-1.08) halves of follow-up. HRs were similar for major causes of death and time-varying analyses.

Source:

Loftfield E, et al. (2024, June 3). JAMA Netw Open. Multivitamin Use and Mortality Risk in 3 Prospective US Cohorts. https://pubmed.ncbi.nlm.nih.gov/38922615/