Diabetes Res Clin Pract

Elevated trigylcerides may increase T2DM risk in young adults

February 14, 2024

Persistent hypertriglyceridemia was significantly associated with an increased risk of type 2 diabetes, independent of lifestyle-related factors, in this large, prospective cohort study of young adults from the South Korean National Health Insurance service database.

• This study included 1,840,251 participants ages 20 to 39 years who'd undergone four consecutive annual health checkups and had no history of type 2 diabetes.
• Participants were categorized into five groups (exposure score 0-4) based on the frequencies of hypertriglyceridemia diagnosis over a four-year period. The primary outcome was newly diagnosed type 2 diabetes. Exploratory analyses were performed for the different subgroups.
• During a follow-up period of 6.53 years, 40,286 participants developed type 2 diabetes.
• The cumulative incidence of type 2 diabetes significantly increased with higher exposure scores for hypertriglyceridemia (log-rank test, P<0.001).
• For individuals with exposure scores of 1, 2, 3, and 4, the multivariable-adjusted hazard ratios for incident diabetes were 1.674 (95% confidence interval [CI], 1.619-1.732), 2.192 (95% CI, 2.117-2.269), 2.637 (95% CI, 2.548-2.73), and 3.715 (95% CI, 3.6-3.834) respectively, compared with those with an exposure score of 0.

Source:

Lee MK, et al. (2024, January 21). Diabetes Res Clin Pract. Cumulative exposure to hypertriglyceridemia and risk of type 2 diabetes in young adults. https://pubmed.ncbi.nlm.nih.gov/38262520/