Ann Intern Med

No link found between aluminum exposure from vaccines and 50 pediatric conditions

July 17, 2025

No evidence was found for increased risks of autoimmune, atopic/allergic, or neurodevelopmental conditions linked to early-childhood vaccines containing aluminum adjuvants, in this cohort study of around 1.2 million children. For some rarer outcomes, small relative effects weren’t able to be statistically excluded.

Study details: This nationwide Danish cohort study (N=1,224,176 children born 1997-2018) examined links between cumulative aluminum exposure from childhood vaccinations received in the first two years of life and incidence of 50 chronic disorders. Conditions included autoimmune disorders (e.g., dermatologic, rheumatic, endocrinologic, GI), atopic/allergic conditions (e.g., asthma, atopic dermatitis, allergies) and neurodevelopmental disorders (e.g., autism spectrum disorder, ADHD). Follow-up extended from 2 years of age through age 5, death, loss of follow-up, or December 31, 2020 (whichever came first). Cox proportional hazards regression was used to assess associations.

Results: Adjusted hazard ratios for every 1-mg rise in aluminum exposure: 0.98 (95% confidence interval [CI], 0.94 - 1.02) for autoimmune disorders, 0.99 (CI, 0.98 - 1.01) for atopic/ allergic disorders, and 0.93 (CI, 0.90 - 0.97) for neurodevelopmental disorders.

Source:

Andersson NW, et al. (2025, July 15). Ann Intern Med. Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood : A Nationwide Cohort Study. https://pubmed.ncbi.nlm.nih.gov/40658954/