JAMA Netw Open

Olive oil intake and dementia-related mortality risk: What's the association?

May 8, 2024

In a prospective cohort study of 92,383 adults observed over 28 years, the consumption of more than 7 grams/day of olive oil was associated with a 28% lower risk of dementia-related death compared with never or rarely consuming olive oil, irrespective of diet quality.

Study results:

• Of 92,383 participants, 60,582 (65.6%) were women and the mean age was 56.4 years. During 28 years of follow-up, 4,751 dementia-related deaths occurred.
• Individuals who were homozygous for the apolipoprotein ε4 (APOE ε4) allele were 5 to 9 times more likely to die with dementia.
• Consuming at least 7 grams/day of olive oil was associated with a 28% lower risk of dementia-related death (adjusted pooled HR, 0.72) compared with never or rarely consuming olive oil (P for trend < .001); results were consistent after further adjustment for APOE ε4.
• In modeled substitution analyses, replacing 5 grams/day of margarine and mayonnaise with the equivalent amount of olive oil was associated with an 8% to 14% lower risk of dementia mortality. Substitutions for other vegetable oils or butter were not significant.

Source:

Tessier AJ, et al. (2024, May 1). JAMA Netw Open. Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death. https://pubmed.ncbi.nlm.nih.gov/38709531/