MMWR

Pediatric flu deaths hit record high in 2024–25 season

September 29, 2025

During the 2024–25 influenza season, the U.S. reported 280 influenza-associated pediatric deaths—the highest number since national reporting began in 2004, excluding the 2009 H1N1 pandemic. The median age at death was 7 years, and 56% had at least one underlying medical condition, most commonly neurologic disorders. Notably, 89% of vaccine-eligible children with known vaccination status were not fully vaccinated. Influenza A viruses accounted for 86% of deaths, with H1N1 and H3N2 subtypes nearly evenly split.

Clinical complications included shock/sepsis (50%), pneumonia (38%), and ARDS (28%). Antiviral treatment was documented in only 40% of cases, with lower usage among children who died outside hospital settings. Median time from symptom onset to death was just 4 days.

This season was classified as high severity across all age groups. CDC urges annual influenza vaccination for all individuals aged ≥6 months without contraindications, especially those with underlying conditions. Early recognition and treatment are critical, particularly for children presenting with respiratory symptoms.

Source:

Reinhart K, et al. (2025, September 25). MMWR Morb Mortal Wkly Rep. Influenza-Associated Pediatric Deaths - United States, 2024-25 Influenza Season. https://pubmed.ncbi.nlm.nih.gov/40996933/