CDC

Updated COVID-19 vaccines linked to decreased pediatric ED visits

December 16, 2025

Following ACIP’s June 2024 recommendation for universal vaccination (≥6 months), investigators used a test-negative case-control design within CDC’s nine-state VISION network to assess vaccine effectiveness (VE) against COVID-19–related ED/urgent care visits from August 2024 to September 2025. VE was 76% (95% confidence interval [CI], 58%–87%) for children aged 9 months to 4 years and 56% (95% CI, 35%–70%) for ages 5 to 17 during the first 7 to 179 days post-dose.

Source:

Irving SA, et al. (2025, December 11). MMWR Morb Mortal Wkly Rep. Effectiveness of 2024-2025 COVID-19 Vaccines in Children in the United States - VISION, August 29, 2024-September 2, 2025. https://www.cdc.gov/mmwr/volumes/74/wr/mm7440a1.htm