J Infect Dis

Which factors are associated with recurrent UTIs in women with cystitis?

August 6, 2024

The significant risk of recurrent UTIs (rUTIs) among women with cystitis is worrisome, particularly given reports indicating a rise in UTI incidence. Evaluating the epidemiology of rUTIs could help in the development of effective preventive strategies.

• In this study, 2016-2020 EHR data from Kaiser Permanente Southern California was used to assess rUTI factors in women with cystitis. rUTI was defined as ≥3 UTI within 365 days or ≥2 UTI within 180 days.
• Among 374,171 women with an index uUTI, 14.5% had rUTI. A higher proportion of women with rUTI compared with those without rUTI were age 18-27 or ≥78 years at index uUTI (19.7% vs. 18.7% and 9.0% vs. 6.0%, respectively), were immunocompromised, or had a positive urine culture at index uUTI.
• In multivariable analyses, characteristics associated with rUTI included younger or older age (48-57 years vs. 18-27 years, aRR=0.83; ≥78 vs. 18-27 years, aRR=1.07), Charlson Comorbidity Index (≥3 vs. 0, aRR=1.12), and diabetes mellitus (aRR=1.07).
• More frequent prior year outpatient and ED encounters, oral antibiotic prescriptions, oral contraceptive prescriptions, positive culture at index uUTI, and antibiotic-resistant organisms were also associated with increased risk of rUTI.

Source:

Ackerson BK, et al. (2024, June 28). J Infect Dis. Risk factors for recurrent urinary tract infections among women in a large integrated health care organization in the United States. https://pubmed.ncbi.nlm.nih.gov/38941351/