NIH

Zebra of the Week: Autoerythrocyte sensitization syndrome

June 16, 2025

Autoerythrocyte sensitization syndrome, also known as Gardner-Diamond syndrome or psychogenic purpura, is a rare condition characterized by spontaneous, painful bruising—typically on the limbs or face—often triggered by emotional stress or minor trauma. The bruises may be preceded by burning or swelling and aren't explained by underlying hematologic or autoimmune disorders. Most commonly affecting adult women with psychological stress or psychiatric comorbidities, the syndrome is thought to involve an autoimmune or psychogenic mechanism, though its pathophysiology remains unclear. Diagnosis is clinical and one of exclusion, often after extensive negative workups. While the condition doesn’t cause long-term physical harm, it can be distressing and is best managed with supportive care, including psychological evaluation and therapy.

Source:

(Accessed 2025, June 13). NIH. Autoerythrocyte sensitization syndrome. https://rarediseases.info.nih.gov/diseases/6481/autoerythrocyte-sensitization-syndrome