Lybalvi

Adult Dosing .

Dosage forms:  TAB: 5 mg/10 mg, 10 mg/10 mg, 15 mg/10 mg, 20 mg/10 mg

schizophrenia

[10 mg/10 mg-20 mg/10 mg PO qd]

Start: 5 mg/10 mg-10 mg/10 mg PO qd, then may incr. by 5 mg/day olanzapine qwk; Max: 20 mg/10 mg/day; Info: start 5 mg/10 mg PO qd in non-smoker, elderly or female pts or if hypotension risk; periodically reassess need for tx; do not cut/crush/chew tab

bipolar I disorder, manic/mixed

[monotherapy]

Dose: 5 mg/10 mg-20 mg/10 mg PO qd; Start: 10 mg/10 mg-15 mg/10 mg PO qd, then may incr. by 5 mg/day olanzapine no more frequently than q24h; Max: 20 mg/10 mg/day; Info: for acute and maint. tx; start 5 mg/10 mg PO qd in non-smoker, elderly or female pts or if hypotension risk; periodically reassess need for tx; do not cut/crush/chew tab

[valproate or lithium adjunct]

Dose: 10 mg/10 mg-20 mg/10 mg PO qd; Start: 10 mg/10 mg PO qd, then may incr. by 5 mg/day olanzapine qwk; Max: 20 mg/10 mg/day; Info: for acute tx; start 5 mg/10 mg PO qd in non-smoker, elderly or female pts or if hypotension risk; periodically reassess need for tx; do not cut/crush/chew tab

renal dosing

[see below]

eGFR <15: avoid use

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.