L-arginine ethyl ester dichloride

Reported Doses

Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies with variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely

Special Note

[formulation clarification]

Info: see arginine for FDA-approved Rx product; all other preparations are not FDA-approved

Effectiveness Ratings

[see Herb & Supplement Effectiveness Rating Definitions table]

anemia

[Insufficient Evidence]

Dose: 1.3 g PO qd; Info: for patients with chronic kidney disease

angina

[Possibly Effective]

Dose: 2 g PO tid; Alt: 6 g PO qd

ARDS prevention

[Insufficient Evidence]

Dose: 3 g PO qd; Start: 2nd or 3rd trimester; Info: for prevention in infants

athletic performance

[Insufficient Evidence]

Dose: 0.15 g/kg/dose PO x1 given 60-90min before performance; Alt: 1.2-3 g PO qd; 6 g PO qd given 90min before training; 6 g/250 mL water PO x1 given 180min before exercise

beta-thalassemia, peds patients

[Insufficient Evidence]

Dose: 0.1 mg/kg/dose PO qd; Info: for patients 6-18 yo with pulmonary HTN; used with conventional tx

CABG

[Insufficient Evidence]

Dose: 30 g (10% solution) IV x1 during surgery; Alt: 7.5 g injection in 500 mL cardioplegic solution x1

CHF

[Insufficient Evidence]

Dose: 15 g PO qd; used with conventional tx

cognitive impairment

[Insufficient Evidence]

Dose: 1.66 g PO bid

COVID-19

[Insufficient Evidence]

Dose: 1.66 g PO bid; Info: used with standard tx

dental caries prevention, adult patients

[Insufficient Evidence]

Dose: apply 1.5% w/w toothpaste bid-tid

dental caries prevention, peds patients

[Insufficient Evidence]

Dose: apply 1.5% w/w toothpaste bid-tid; Alt: 20 mg lozenge PO qd in patients 5-9 yo

dental hypersensitivity

[Insufficient Evidence]

Dose: apply 8% toothpaste bid; Alt: apply 10% gel topically x10min before dental procedure

diabetic foot ulcers

[Insufficient Evidence]

Dose: 7 g PO bid; Info: used with L-glutamine and hydroxymethylbutyrate

erectile dysfunction

[Possibly Effective]

Dose: 2.5-5 mg PO qd; Alt: 0.69-5 g/day PO divided qd-bid; 2 g PO tid; Info: commonly used with PDE5 inhibitor

heart failure

[Insufficient Evidence]

Dose: 1000 mg PO tid

heart transplant

[Insufficient Evidence]

Dose: 6 g PO bid

HTN

[Possibly Effective]

Dose: 4-24 g PO qd; Alt: 3 g PO tid

HTN, pregnancy-induced

[Possibly Effective]

Dose: 20 g IV qd; Alt: 3 g PO qd starting 14 wk gestation

impaired glucose tolerance

[Insufficient Evidence]

Dose: 3.2 g PO bid

infertility in patients of childbearing potential

[Insufficient Evidence]

Dose: 16 g PO qd

interstitial cystitis

[Insufficient Evidence]

Dose: 1.5 g PO qd

intrauterine growth restriction

[Insufficient Evidence]

Dose: 3 g PO qd; Info: up to 20 g/day IV has been used; for pregnant patients with ultrasound-diagnosed intrauterine growth restriction

MELAS syndrome

[Insufficient Evidence]

Dose: 0.5 g/kg/dose IV x1 given within 1h of signs/symptoms; Alt: 4-24 g PO qd

muscle wasting, HIV/AIDS-related

[Insufficient Evidence]

Dose: 14 g/day PO divided bid

muscular dystrophy, peds patients

[Insufficient Evidence]

Dose: 2.5 g PO tid; Info: used with metformin

necrotizing enterocolitis prevention

[Possibly Effective]

Dose: 260 mg/kg/day PO divided qd-bid; Info: used in preterm neonates

nitrate tolerance

[Insufficient Evidence]

Dose: 700 mg PO qid

obesity

[Insufficient Evidence]

Dose: 3 g PO tid; Alt: 2-6 g PO qd

oral mucositis

[Insufficient Evidence]

Dose: 7 g PO bid; Info: product containing L-arginine, L-glutamine, hydroxymethylbutyrate

pain, acute

[Insufficient Evidence]

Dose: 555 mg PO x1; Start: 30min before surgery; Info: used with ibuprofen

periodontitis

[Insufficient Evidence]

Dose: 1 g PO tid; Start: after scaling and root planing

peripheral arterial disease

[Possibly Effective]

Dose: 24 g/day PO divided tid; Alt: 8 g IV in 50 mL saline bid; 3.3-6.6 g PO qd

polycystic ovary syndrome

[Insufficient Evidence]

Dose: 1600 mg PO qd; Info: used with N-acetyl cysteine

postop pain

[Insufficient Evidence]

Dose: 370 mg PO x1; Start: 1h before surgery or immediately after surgery; Info: used with ibuprofen and with or without dexamethasone

postop recovery

[Insufficient Evidence]

Dose: 7-14 g PO qd; Start: 2-4wk before surgery; Info: used with L-glutamine and hydroxymethylbutyrate

pre-eclampsia

[Possibly Effective]

Dose: 30 g IV x1; Alt: 20 g IV qd; 3-6.6 g PO qd

pressure ulcer

[Insufficient Evidence]

Dose: 7.4 g PO/NG bid; Info: may dilute with 250 mL water; used with L-glutamine and hydroxymethylbutyrate

preterm labor prevention

[Insufficient Evidence]

Dose: 3-6.6 g PO qd; Start: 2nd or 3rd trimester

PTCA restenosis prevention

[Insufficient Evidence]

Dose: 600 mg/6 mL injection via stent catheter x1

radiation dermatitis

[Insufficient Evidence]

Dose: 7 g PO bid; Start: 1st day of XRT; Info: used with L-glutamine and hydroxymethylbutyrate

renal transplant

[Insufficient Evidence]

Dose: 0.5 g/kg/h IV x1, then 0.75 g/kg/dose IV qd x3 days; Start: 2h before surgery

sexual dysfunction

[Insufficient Evidence]

Dose: 200 mg PO qd; Alt: 400 mg PO bid

sickle cell disease

[Insufficient Evidence]

Dose: 0.1 g/kg/dose PO/IV tid x5 days; Info: for use in adults and peds patients 3 yo and older

stress

[Insufficient Evidence]

Dose: 50 mg PO x1; Info: used with L-theanine