coenzima Q-10

Reported Doses

Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely

Effectiveness Ratings

[see Herb & Supplement Effectiveness Rating Definitions table]

ADHD, peds pts

[Insufficient Evidence]

Dose: 1-3 mg/kg/dose PO qd; Info: for pts 6-16 yo; used w/ atomoxetine

age-related macular degeneration

[Insufficient Evidence]

Dose: 10 mg PO qd; Info: used w/ acetyl-L-carnitine and omega-3 fatty acids

angina

[Insufficient Evidence]

Dose: 60 mg PO qd; Alt: 50 mg PO tid

anthracycline-induced cardiotoxicity, peds pts

[Insufficient Evidence]

Dose: 100 mg PO bid; Info: for pts 3-12 yo

asthma

[Insufficient Evidence]

Dose: 120 mg PO qd; Info: may give in divided doses; used w/ conventional tx

autism spectrum disorder, peds pts

[Insufficient Evidence]

Dose: 50 mg PO bid; Start: 50 mg PO qd x7 days; Info: for pts 3-6 yo

bipolar disorder

[Insufficient Evidence]

Dose: 800 mg PO qd; Info: may give in divided doses

BPH

[Insufficient Evidence]

Dose: 100 mg PO qd; Info: used w/ L-carnitine and finasteride

cancer

[Insufficient Evidence]

Dose: 150 mg PO bid

cardiac event prevention, post-MI

[Possibly Effective]

Dose: 60 mg PO bid starting w/in 72h of MI; Alt: 250 mg NG x1, then 150 mg NG tid

cardiomyopathy, dilated

[Insufficient Evidence]

Dose: 3-10 mg/kg/day PO divided bid-tid; Alt: 10 mg/kg/dose PO qd; Info: for use in peds pts

cardiomyopathy, hypertrophic

[Insufficient Evidence]

Dose: 120-240 mg PO qd; Info: may give in divided doses

cardiovascular dz

[Insufficient Evidence]

Dose: 100 mg PO bid

cerebellar ataxia

[Insufficient Evidence]

Dose: 30 mg/kg/dose PO qd

CHF

[Possibly Effective]

Dose: 30-300 mg/day PO divided bid-tid; Alt: 2 mg/kg/day PO divided bid-tid; 30 mg PO qd; 600 mg PO qd; Info: may give doses >100 mg/day in divided doses; used w/ conventional tx

coenzyme Q10 deficiency, adult pts

[Likely Effective]

Dose: 150-2400 mg/day PO divided qd-tid

coenzyme Q10 deficiency, peds pts

[Likely Effective]

Dose: 60-250 mg/day PO divided qd-tid; Alt: up to 30 mg/kg/day PO divided tid

COPD

[Insufficient Evidence]

Dose: 90 mg PO qd

critical illness (trauma)

[Insufficient Evidence]

Dose: 400 mg PO qd; Info: may give in divided doses

cyclic vomiting syndrome

[Insufficient Evidence]

Dose: 10 mg/kg/day PO divided bid; Max: 200 mg bid; Info: for use in adult and peds pts

diabetic neuropathy

[Possibly Effective]

Dose: 400 mg PO qd; Alt: 100 mg PO tid; Info: may give doses >100 mg/day in divided doses; used w/ or w/o pregabalin

dry eye dz

[Insufficient Evidence]

Dose: 1 gtt in eye(s) bid-qid; Info: 1:1 sol w/ cross-linked hyaluronic acid

fatigue

[Insufficient Evidence]

Dose: 60-500 mg PO qd; Info: may give doses >100 mg/day in divided doses

fibromyalgia

[Possibly Effective]

Dose: 300-400 mg PO qd; Info: may give in divided doses

Friedreich ataxia

[Insufficient Evidence]

Dose: 200 mg PO bid; Info: used w/ vitamin E

hearing loss

[Insufficient Evidence]

Dose: 160 mg PO qd; Info: may give in divided doses

hepatotoxicity, toxin-induced

[Insufficient Evidence]

Dose: 200 mg PO bid; Info: used w/ acetyl-L-carnitine and alpha-lipoic acid

HTN

[Insufficient Evidence]

Dose: 100-900 mg PO qd; Info: may give in divided doses; used w/ or w/o conventional tx

hyperlipidemia

[Insufficient Evidence]

Dose: 100-500 mg PO qd; Alt: 2 mg PO qd; Info: may give doses >100 mg/day in divided doses

ischemic reperfusion injury

[Possibly Effective]

Dose: 150-300 mg/day PO divided qd-tid x7-14 days before bypass or vascular surgery; Alt: 5 mg/kg/dose IV x1 given 2h before bypass or vascular surgery

lichen planus

[Insufficient Evidence]

Dose: 120 mg mucoadhesive tab topically tid

male infertility

[Insufficient Evidence]

Dose: 200-400 mg PO qd; Alt: 10 mg PO tid; 20 mg PO bid; Info: may give doses >100 mg/day in divided doses

maternally inherited diabetes mellitus and deafness

[Insufficient Evidence]

Dose: 150 mg PO qd; Info: may give in divided doses

migraine prophylaxis, adult pts

[Possibly Effective]

Dose: 100-150 mg PO qd; Info: may give in divided doses

migraine prophylaxis, peds pts

[Possibly Effective]

Dose: 1-3 mg/kg/dose PO qd; Alt: 100 mg PO qd; 30 mg PO qd if wt <30 kg; 60 mg PO qd if wt >30 kg

mitochondrial myopathies

[Likely Effective]

Dose: 150-160 mg PO qd; Alt: 2 mg/kg/dose PO qd; Info: up to 3000 mg/day has been used; may give in divided doses

multiple sclerosis

[Possibly Effective]

Dose: 500 mg PO qd; Info: may give in divided doses

muscular dystrophy

[Possibly Effective]

Dose: 100 mg PO qd

myalgia, statin-induced

[Insufficient Evidence]

Dose: 100 mg PO qd-bid; Alt: 50 mg PO bid

myocarditis

[Insufficient Evidence]

Dose: 10 mg PO tid

myopathy, statin-induced

[Insufficient Evidence]

Dose: 100 mg PO bid; Alt: 60 mg PO qid

nonalcoholic fatty liver dz

[Insufficient Evidence]

Dose: 100 mg PO qd

periodontitis

[Insufficient Evidence]

Dose: 50 mg PO qd; Alt: apply gel topically into the periodontal pocket qd

Peyronie dz

[Possibly Effective]

Dose: 300 mg PO qd; Info: may give in divided doses

polycystic ovary syndrome

[Insufficient Evidence]

Dose: 100-200 mg PO qd; Info: may give in divided doses

Prader-Willi syndrome, peds pts

[Insufficient Evidence]

Dose: 2.5 mg/kg/dose PO qd

pre-eclampsia

[Insufficient Evidence]

Dose: 100 mg PO bid until term or delivery; Start: 20 wk gestation

renal failure

[Insufficient Evidence]

Dose: 180 mg PO qd; Info: may give in divided doses

ulcerative colitis

[Insufficient Evidence]

Dose: 100 mg PO bid

wrinkled skin

[Insufficient Evidence]

Dose: apply 1% cream topically bid

xerostomia

[Insufficient Evidence]

Dose: 100 mg PO qd